Computational analysis of lupenone derivatives as potential inhibitor of human papillomavirus oncoprotein E6 associated cervical cancer

Computational analysis of lupenone derivatives as potential inhibitor of human papillomavirus oncoprotein E6 associated cervical cancer

Abstract Cervical cancer remains a major global health challenge, largely driven by persistent infections with high-risk human papillomavirus (HPV). Although preventive vaccines have reduced cervical cancer incidence in some settings, effective therapeutic strategies for established HPV-associated m...

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Main Authors: Saurav Kumar Mishra, Mir Md. Shaheen, Sharifa Sultana, Al-Anood M. Al-Dies, Jehad Zuhair Tayyeb, Taha Alqahtani, Yewulsew Kebede Tiruneh, Gabriel Christian de Farias Morais, Jonas Ivan Nobre Oliveira, Magdi E. A. Zaki
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Druglikeness
DFT
Molecular docking
Molecular dynamic simulation
ADMET
Human papilloma virus
Online Access:https://doi.org/10.1038/s41598-025-96667-3
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https://doi.org/10.1038/s41598-025-96667-3

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