Effects of Somatic Mutations Are Associated with SNP in the Progression of Individual Acute Myeloid Leukemia Patient: The Two-Hit Theory Explains Inherited Predisposition to Pathogenesis

Effects of Somatic Mutations Are Associated with SNP in the Progression of Individual Acute Myeloid Leukemia Patient: The Two-Hit Theory Explains Inherited Predisposition to Pathogenesis

This study evaluated the effects of somatic mutations and single nucleotide polymorphisms (SNPs) on disease progression and tried to verify the two-hit theory in cancer pathogenesis. To address this issue, SNP analysis was performed using the UCSC hg19 program in 10 acute myeloid leukemia patients (...

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Bibliographic Details
Main Authors: Soyoung Park, Youngil Koh, Sung-Soo Yoon
Format: Article
Language:English
Published: BioMed Central 2013-03-01
Series:Genomics & Informatics
Subjects:
acute myeloid leukemia
high-throughput nucleotide sequencing
point mutation
single nucleotide polymorphism
Online Access:http://genominfo.org/upload/pdf/gni-11-34.pdf
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http://genominfo.org/upload/pdf/gni-11-34.pdf

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