The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding

The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding

Abstract Background Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contrast to the multiple Dicer-like proteins found in flies and plants. Here, we focus on the functions of the human Dicer (hDicer) helicase domain. The helicase dom...

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Main Authors: Kinga Ciechanowska, Agnieszka Szczepanska, Kamil Szpotkowski, Klaudia Wojcik, Anna Urbanowicz, Anna Kurzynska-Kokorniak
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Biology
Subjects:
Helicase
ATPase
RNase III
Dicer
RNA–protein complexes
Online Access:https://doi.org/10.1186/s12915-024-02082-x
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https://doi.org/10.1186/s12915-024-02082-x

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