Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo

Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo

IntroductionVascular endothelial growth factor (VEGF) inhibition is currently the first-line therapy for various retinal vascular disorders, however there is a strong need to develop novel therapies to target other molecules involved in the angiogenic process. In addition to well-known antibiotic pr...

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Main Authors: María Lina Formica, María Constanza Paz, María Victoria Vaglienti, Paula Virginia Subirada, Yamila Fernández, Mariana Belén Joray, José Domingo Luna, Pablo Federico Barcelona, Santiago Daniel Palma, María Cecilia Sánchez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
doxycycline
matrix metalloproteinases
neovascularization
oxygen-induced retinopathy
pigmentary epithelium-derived factor
vascular endothelial growth factor
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1561250/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1561250/full

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