High-resolution transcriptome analysis on a mouse model of neonatal hypoxic-ischemic encephalopathy using single-nucleus RNA-seq

High-resolution transcriptome analysis on a mouse model of neonatal hypoxic-ischemic encephalopathy using single-nucleus RNA-seq

Neonatal hypoxic-ischemic encephalopathy (HIE) encompasses brain injuries resulting from dysregulated oxygen or blood flow to the brain before, during, or immediately after birth. During the acute phase, neuronal damage is driven by excitotoxicity, with permanent injury manifesting over the subseque...

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Bibliographic Details
Main Authors: Nao Wakui, Takashi Shimbo, Morifumi Hanawa, Tomomi Kitayama, Yukari Yamamoto, Yuya Ouchi, Kotaro Saga, Aiko Okada, Kazuya Mimura, Katsuto Tamai, Masayuki Endo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Neonatal hypoxic-ischemic encephalopathy
Mouse model
Single-nucleus RNA sequencing
Neuronal damage
Hippocampus
Interferon activation
Online Access:http://www.sciencedirect.com/science/article/pii/S240558082500113X
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