Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.

Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia.

Human APOBEC3 cytidine deaminases are intrinsic resistance factors to HIV-1. However, HIV-1 encodes a viral infectivity factor (Vif) that degrades APOBEC3 proteins. In vitro APOBEC3F (A3F) anti-HIV-1 activity is weaker than A3G but is partially resistant to Vif degradation unlike A3G. It is unknown...

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Main Authors: Ping An, Sudhir Penugonda, Christian W Thorball, Istvan Bartha, James J Goedert, Sharyne Donfield, Susan Buchbinder, Elizabeth Binns-Roemer, Gregory D Kirk, Wenyan Zhang, Jacques Fellay, Xiao-Fang Yu, Cheryl A Winkler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005921&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005921&type=printable

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