Nanodesigner: resolving the complex-CDR interdependency with iterative refinement

Abstract Camelid heavy-chain only antibodies consist of two heavy chains and single variable domains (VHHs), which retain antigen-binding functionality even when isolated. The term “nanobody” is now more generally used for describing small, single-domain antibodies. Several antibody generative model...

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Bibliographic Details
Main Authors: Melissa Maria Rios Zertuche, Şenay Kafkas, Dominik Renn, Magnus Rueping, Robert Hoehndorf
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Cheminformatics
Subjects:
Online Access:https://doi.org/10.1186/s13321-025-01069-2
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