Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

Abstract Targeting the photosensitive ion channel channelrhodopsin‐2 (ChR2) to the retinal circuitry downstream of photoreceptors holds promise in treating vision loss caused by retinal degeneration. However, the high intensity of blue light necessary to activate channelrhodopsin‐2 exceeds the safet...

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Main Authors: Abhishek Sengupta, Antoine Chaffiol, Emilie Macé, Romain Caplette, Mélissa Desrosiers, Maruša Lampič, Valérie Forster, Olivier Marre, John Y Lin, José‐Alain Sahel, Serge Picaud, Deniz Dalkara, Jens Duebel
Format: Article
Language:English
Published: Springer Nature 2016-09-01
Series:EMBO Molecular Medicine
Subjects:
channelrhodopsin
optogenetics
primate
retina
vision restoration
Online Access:https://doi.org/10.15252/emmm.201505699
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https://doi.org/10.15252/emmm.201505699

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