The Role of Anti-Interferon-α Autoantibodies in Severe COVID-19: Implications for Vaccination Prioritization

The Role of Anti-Interferon-α Autoantibodies in Severe COVID-19: Implications for Vaccination Prioritization

<b>Background/Objectives</b>: Neutralizing autoantibodies against type I interferons, particularly interferon-alpha (IFN-α), have been implicated in severe COVID-19 outcomes. This study investigated the prevalence and functional significance of anti-IFN-α autoantibodies (AAbs) in hospita...

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Main Authors: Xin Rong Lim, Shiyu Liu, Hwee Siew Howe, Khai Pang Leong, Elampirai Elangovan, Chiung-Hui Huang, Kok Ooi Kong, Bernard Yu Hor Thong, Shawn Vasoo, Bernard Pui Lam Leung
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
IFN-α
type I interferon
autoantibody
SARS-CoV-2
COVID-19 vaccination
Online Access:https://www.mdpi.com/2076-393X/13/7/742
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