The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells

The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells

Abstract Background Cellular prion protein (PrPC) is a widely expressed membrane-anchored glycoprotein, which has been associated with the development and progression of several types of human malignancies, controlling cancer stem cell activity. However, the different molecular mechanisms regulated...

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Bibliographic Details
Main Authors: Alessandro Corsaro, Irene Dellacasagrande, Michele Tomanelli, Aldo Pagano, Federica Barbieri, Stefano Thellung, Tullio Florio
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer Cell International
Subjects:
Glioblastoma stem cells
Prion protein
Pro-prion, Wnt/β-catenin pathway.
Online Access:https://doi.org/10.1186/s12935-024-03581-1
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https://doi.org/10.1186/s12935-024-03581-1

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