Protease-responsive protein hydrogel enabling spatiotemporal ClO2 release for precision treatment of intracellular infections and periodontitis

Protease-responsive protein hydrogel enabling spatiotemporal ClO2 release for precision treatment of intracellular infections and periodontitis

Antibiotics exhibit limited efficacy against intracellular pathogens and biofilms in periodontitis, thus often leading to drug resistance and compromised the long-term therapeutic outcomes. To address this, we developed an injectable, protease-responsive protein hydrogel (CD/BSA/GEL) for inflammatio...

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Bibliographic Details
Main Authors: Xianxian Huang, Yingjuan Zhang, Yonghui Huang, Qiurui Hu, Zhisong Mai, Yuan Qin, Cui Huang, Yanhua Wei, Fengyuan Zhou, Yicai Luo, Yinge Wei, Xinglu Jiang, Hongbing Liao
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials & Design
Subjects:
Periodontitis
Intracellular antimicrobial
Gelatin
Protein hydrogel
Chlorine dioxide
Protease-responsive
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127525007415
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