The African swine fever virus B125R protein antagonizes JAK-STAT signalling by promoting the degradation of IFNAR2

The African swine fever virus B125R protein antagonizes JAK-STAT signalling by promoting the degradation of IFNAR2

Abstract African swine fever (ASF) is a highly contagious and severe hemorrhagic disease caused by African swine fever virus (ASFV). Currently, few safe and effective vaccines or antiviral drugs are available for its prevention. Interferon (IFN), a key component of innate antiviral immunity, induces...

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Main Authors: Jun-Hao Fan, Yan-Yan Zhao, Yu-He Ma, Xiao-Ya Pan, Han-Cheng Shao, Meng-Hui Zi, Haojie Ren, Yuhang Zhang, Shichong Han, Bo Wan, Gai-Ping Zhang, Wen-Rui He
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Veterinary Research
Subjects:
African swine fever virus
JAK-STAT signalling pathway
IFN-β
B125R protein
IFNAR2
autophagy
Online Access:https://doi.org/10.1186/s13567-025-01523-x
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https://doi.org/10.1186/s13567-025-01523-x

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