PDH Inhibition in <i>Drosophila</i> Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models

PDH Inhibition in <i>Drosophila</i> Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models

<b>Background/Objectives:</b> Chemotherapy-induced peripheral neuropathy (CIPN) is a significant dose-limiting side effect of many effective anticancer agents, including vincristine. While CIPN adversely affects both oncological outcomes and the quality of life for cancer patients, the i...

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Bibliographic Details
Main Authors: Harim Song, Sohee Kim, Ji Eun Han, Kyong-hwa Kang, Hyongjong Koh
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomedicines
Subjects:
chemotherapy-induced peripheral neuropathy (CIPN)
vincristine
<i>Drosophila</i>
thermal nociception
pyruvate dehydrogenase (PDH)
Online Access:https://www.mdpi.com/2227-9059/13/4/783
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