NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes

NF1 expression profiling in IDH-wildtype glioblastoma: genomic associations and survival outcomes

Abstract Background NF1 inactivation is associated with sensitivity to MEK inhibitor targeted therapy in low-grade and some high-grade gliomas. NF1 loss may also be a harbinger of exploitable vulnerabilities in IDH-wildtype glioblastoma (GBM). Accurate and consistent detection of NF1 loss, however,...

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Main Authors: Michael Chang, Mohamed Sherief, Maria Ioannou, Viveka Chinnasamy, Lucy Chen, Michael Frost, Michelle Mattson-Hoss, Herb Sarnoff, David O. Kamson, Matthias Holdhoff, Debraj Mukherjee, Chetan Bettegowda, Jordina Rincon-Torroella, Victoria Croog, Peng Huang, Fausto J. Rodriguez, Calixto-Hope G. Lucas, Karisa C. Schreck
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Acta Neuropathologica Communications
Subjects:
Neurofibromin
NF1
Biomarker
Glioblastoma
High-grade glioma
Online Access:https://doi.org/10.1186/s40478-024-01875-z
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https://doi.org/10.1186/s40478-024-01875-z

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