Bone marrow microenvironment in myelodysplastic neoplasms: insights into pathogenesis, biomarkers, and therapeutic targets

Bone marrow microenvironment in myelodysplastic neoplasms: insights into pathogenesis, biomarkers, and therapeutic targets

Abstract Myelodysplastic neoplasms (MDS) represent a heterogeneous group of malignant hematopoietic stem and progenitor cell (HSPC) disorders characterized by cytopenia, ineffective hematopoiesis, as well as the potential to progress to acute myeloid leukemia (AML). The pathogenesis of MDS is influe...

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Main Authors: Forouzan Bahmani, Maryam Shayanmanesh, Mahdi Safari, Amirarsalan Alaei, Yasaman Pouriafar, Zahra Rasti, Farhad Zaker, Shahrbano Rostami, Fatemeh Damerchiloo, Majid Safa
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cancer Cell International
Subjects:
Myelodysplastic neoplasms
Hematopoietic stem and progenitor cells
Bone marrow microenvironment
Ineffective hematopoiesis
Inflammation
Innovative therapies
Online Access:https://doi.org/10.1186/s12935-025-03793-z
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https://doi.org/10.1186/s12935-025-03793-z

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