Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration

Therapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration

Abstract Background Intervertebral disc degeneration (IDD) is a leading cause of low back pain, often linked to inflammation and pyroptosis in nucleus pulposus (NP) cells. The role of Periostin (POSTN) in IDD remains unclear. Objective This study aims to investigate the influence of POSTN on pyropto...

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Bibliographic Details
Main Authors: Daxue Zhu, Zhaoheng Wang, Shijie Chen, Yanhu Li, Xuewen Kang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
Periostin
Interferon regulatory factor 2
Intervertebral disc degeneration
Nucleus pulposus
Pyroptosis
Notch1
Online Access:https://doi.org/10.1186/s12974-025-03335-4
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https://doi.org/10.1186/s12974-025-03335-4

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