Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling

Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling

BackgroundThe molecular non-genetic changes of resistance to sotorasib are currently uncertain. The aim of this study was to generate a sotorasib-resistant cell line via selective pressure and systematically examine the molecular and phenotypic alterations caused by resistance.MethodsMutant NCI-H358...

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Main Authors: Raquel Arantes Megid, Guilherme Gomes Ribeiro, Izabela Natalia Faria Gomes, Ana Carolina Laus, Letícia Ferro Leal, Luciane Sussuchi da Silva, Abu-Bakr Adetayo Ariwoola, Josiane Mourão Dias, Rui Manuel Reis, Renato Jose da Silva-Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
sotorasib
KRAS
NSCLC
sotorasib-resistant
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1537523/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1537523/full

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