From metabolic byproduct to immune modulator: the role of lactate in tumor immune escape

Lactic acid, a key metabolic byproduct within the tumor microenvironment, has garnered significant attention for its role in immune evasion mechanisms. Tumor cells produce and release large amounts of lactic acid into the tumor microenvironment through aberrant glycolysis via the Warburg effect, lea...

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Bibliographic Details
Main Authors: Mengqian Jiang, Yuanchun Wang, Xiaoyong Zhao, Jinming Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1492050/full
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