Higher clozapine concentration-to-dose ratios at week 1 after initiation are associated with increased risk of clozapine-associated fever in Japanese patients with schizophrenia

Higher clozapine concentration-to-dose ratios at week 1 after initiation are associated with increased risk of clozapine-associated fever in Japanese patients with schizophrenia

IntroductionThe clinical use of clozapine in the treatment of schizophrenia is sometimes halted due to its inflammatory side effects. However, no method has been established for preemptively identifying patients who are at high risk for these events. Therefore, in this study, we assessed whether the...

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Main Authors: Yuki Kikuchi, Hiroaki Tanifuji, Mutsumi Sakata, Kazuro Ikawa, Daisuke Kume, Naoki Horikawa, Sota Ueno, Yoshifumi Onuma, Masato Ishihara, Bunichiro Onodera, Takeshi Toraiwa, Hiroshi Komatsu, Toshihiro Sato, Masamitsu Maekawa, Nariyasu Mano, Hiroaki Tomita
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Psychiatry
Subjects:
adverse effect
c-reactive protein
inflammation
pneumonia
myocarditis
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1591568/full
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https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1591568/full

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