Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling

Guanxinning attenuates diabetic myocardial ischemia–reperfusion injury by targeting oral Fusobacterium nucleatum and modulating PTEN signaling

BackgroundThe incidence and severity of diabetic myocardial ischemia reperfusion injury (DMIRI) are increasing, highlighting the urgent need for effective prevention and treatment. Previous studies have revealed that specific oral microbiota (Fusobacterium nucleatum) are closely involved in DMIRI, p...

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Bibliographic Details
Main Authors: Yiwen Li, Qian Xu, Yanfei Liu, Longkun Liu, Wenting Wang, Mengmeng Zhu, Jing Cui, Hongjun Yang, Yue Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
Guanxinning
diabetes mellitus
myocardial ischemia reperfusion injury
oral microbiota
Fusobacterium nucleatum
PTEN
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1581413/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1581413/full

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