Small molecules targeting the eubacterial β-sliding clamp discovered by combined in silico and in vitro screening approaches

Small molecules targeting the eubacterial β-sliding clamp discovered by combined in silico and in vitro screening approaches

Antibiotic resistance stands as the foremost post-pandemic threat to public health. The urgent need for new, effective antibacterial treatments is evident. Protein-protein interactions (PPIs), owing to their pivotal role in microbial physiology, emerge as novel and attractive targets. Particularly p...

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Bibliographic Details
Main Authors: Alessia Caputo, Gian Marco Elisi, Elisabetta Levati, Giulia Barotti, Sara Sartini, Jerome Wagner, Dominique Y. Burnouf, Simone Ottonello, Silvia Rivara, Barbara Montanini
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Bacterial DNA polymerase
protein–protein interaction inhibitors
virtual screening
yeast Bioluminescence Resonance Energy Transfer (yBRET)
antibiotics
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2440861
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https://www.tandfonline.com/doi/10.1080/14756366.2024.2440861

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