Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice

Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice

AAV-PHP.eB is an artificial adeno-associated virus (AAV) that crosses the blood–brain barrier and targets neurons more efficiently than other AAVs when administered systematically. While AAV-PHP.eB has been used in various disease models, its cellular tropism in cerebrovascular diseases remains uncl...

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Bibliographic Details
Main Authors: Rubing Shi, Jing Ye, Ze Liu, Cheng Wang, Shengju Wu, Hui Shen, Qian Suo, Wanlu Li, Xiaosong He, Zhijun Zhang, Yaohui Tang, Guo-Yuan Yang, Yongting Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-02-01
Series:Neural Regeneration Research
Subjects:
aav-php.eb
angiogenesis
basic fibroblast growth factor
gene therapy
ischemic stroke
ly6a
neurogenesis
neurological function
transient middle cerebral artery occlusion
tropism
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01802
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https://journals.lww.com/10.4103/NRR.NRR-D-23-01802

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