Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy

Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy

Abstract The selection of genetically engineered immune or hematopoietic cells in vivo after gene editing remains a clinical problem and requires a method to spare on-target toxicity to normal cells. Here, we develop a base editing approach exploiting a naturally occurring CD33 single nucleotide pol...

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Main Authors: Florence Borot, Olivier Humbert, Jeffrey T. Ehmsen, Emily Fields, Sajeev Kohli, Stefan Radtke, Kyle Swing, Dnyanada Pande, Mark R. Enstrom, George S. Laszlo, Thiyagaraj Mayuranathan, Abdullah Mahmood Ali, Mitchell J. Weiss, Jonathan S. Yen, Gregory A. Newby, Roland B. Walter, David R. Liu, Siddhartha Mukherjee, Hans-Peter Kiem
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59713-2
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https://doi.org/10.1038/s41467-025-59713-2

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