Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives
Abstract A high-fat diet and physical inactivity are key contributors to obesity, predisposing individuals to various chronic diseases, such as cardiovascular disease and diabetes, which involve multiple organs and tissues. To better understand the role of multi-organ interaction mechanisms in the r...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-024-02176-w |
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| _version_ | 1841559817942990848 |
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| author | Zixuan Jia Ziqi Wang Huixin Pan Jing Zhang Qinglu Wang Caixia Zhou Jun Liu |
| author_facet | Zixuan Jia Ziqi Wang Huixin Pan Jing Zhang Qinglu Wang Caixia Zhou Jun Liu |
| author_sort | Zixuan Jia |
| collection | DOAJ |
| description | Abstract A high-fat diet and physical inactivity are key contributors to obesity, predisposing individuals to various chronic diseases, such as cardiovascular disease and diabetes, which involve multiple organs and tissues. To better understand the role of multi-organ interaction mechanisms in the rising incidence of obesity and its associated chronic conditions, treatment and prevention strategies are being extensively investigated. This review examines the signaling mechanisms between different tissues and organs, with a particular focus on the crosstalk between adipose tissue and the muscle, brain, liver, and heart, and potentially offers new strategies for the treatment and management of obesity and its complications. |
| format | Article |
| id | doaj-art-748f28c86cad4f7182360cadc150848e |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-748f28c86cad4f7182360cadc150848e2025-01-05T12:12:21ZengBMCEuropean Journal of Medical Research2047-783X2024-12-0129111110.1186/s40001-024-02176-wCrosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectivesZixuan Jia0Ziqi Wang1Huixin Pan2Jing Zhang3Qinglu Wang4Caixia Zhou5Jun Liu6Graduate School of Education, Shandong Sport UniversityGraduate School of Education, Shandong Sport UniversityGraduate School of Education, Shandong Sport UniversityGraduate School of Education, Shandong Sport UniversityGraduate School of Education, Shandong Sport UniversityGraduate School of Education, Shandong Sport UniversityGraduate School of Education, Shandong Sport UniversityAbstract A high-fat diet and physical inactivity are key contributors to obesity, predisposing individuals to various chronic diseases, such as cardiovascular disease and diabetes, which involve multiple organs and tissues. To better understand the role of multi-organ interaction mechanisms in the rising incidence of obesity and its associated chronic conditions, treatment and prevention strategies are being extensively investigated. This review examines the signaling mechanisms between different tissues and organs, with a particular focus on the crosstalk between adipose tissue and the muscle, brain, liver, and heart, and potentially offers new strategies for the treatment and management of obesity and its complications.https://doi.org/10.1186/s40001-024-02176-wObesityFat tissueMuscleBrainLiverHeart |
| spellingShingle | Zixuan Jia Ziqi Wang Huixin Pan Jing Zhang Qinglu Wang Caixia Zhou Jun Liu Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives European Journal of Medical Research Obesity Fat tissue Muscle Brain Liver Heart |
| title | Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives |
| title_full | Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives |
| title_fullStr | Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives |
| title_full_unstemmed | Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives |
| title_short | Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives |
| title_sort | crosstalk between fat tissue and muscle brain liver and heart in obesity cellular and molecular perspectives |
| topic | Obesity Fat tissue Muscle Brain Liver Heart |
| url | https://doi.org/10.1186/s40001-024-02176-w |
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