Klotho modulation by tempol: a potential therapeutic axis in sepsis

Klotho modulation by tempol: a potential therapeutic axis in sepsis

Abstract Background Sepsis is characterized by massive inflammatory and oxidative stress responses. The imbalance between oxidant and antioxidant activities during sepsis contributes to hyperinflammation, oxidation, endothelin system activation, and apoptosis, key elements of multiorgan failure. The...

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Bibliographic Details
Main Authors: Alaa Al-kadi, Aliaa F. Anter, Remon Roshdy Rofaeil, Mohamed M. Sayed-Ahmed, Sara Mohamed Naguib Abdel Hafez, Al-Shaimaa F. Ahmed
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cardiovascular Disorders
Subjects:
Sepsis
Oxidation
Tempol
Heart
Kidney
Klotho
Online Access:https://doi.org/10.1186/s12872-025-04738-0
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