The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates

The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates

Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZA<sup>R</sup>) primarily related to <i>pncA</i> mutations. However, discordance between phenotypic resistance and conventional <i>pncA</i>-based molecular diagnostics challeng...

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Bibliographic Details
Main Authors: H. M. Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yamin Gao, Shuai Wang, Xinwen Chen, Nanshan Zhong, Htin Lin Aung, Jinxing Hu, Tianyu Zhang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Microorganisms
Subjects:
<i>Mycobacterium tuberculosis</i>
pyrazinamide
drug resistance
<i>clpC1</i>
clinical isolates
molecular diagnosis
Online Access:https://www.mdpi.com/2076-2607/13/6/1401
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