Intestinal microbiota improves inflammation and cognitive function in the brain of a7nAChR deficient rat through the gut brain axis

Intestinal microbiota improves inflammation and cognitive function in the brain of a7nAChR deficient rat through the gut brain axis

Abstract To investigate the role of intestinal flora and cholinergic anti-inflammatory pathways in the gut-brain axis, using oral gavage and intraperitoneal injection of methyllycaconitine (MLA). MLA was administered at a dose of 4 mg/kg for 30 days, either orally or via intraperitoneal injection. R...

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Bibliographic Details
Main Authors: Chi Cao, Shulin Li, Wencheng Wang, Lei Shi, Rui Ma, Bin Zhang, Jianying Tian
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Methyllycaconitine
α7nAChR
Gut-brain axis
Intestinal microbiotas
Inflammation
Online Access:https://doi.org/10.1038/s41598-025-02627-2
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https://doi.org/10.1038/s41598-025-02627-2

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