Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma

Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma

IntroductionMedullary thyroid carcinoma (MTC) is a rare and aggressive thyroid cancer with a challenging prognosis. While the immune microenvironment plays a crucial role in cancer progression, its role in MTC remains underexplored compared to more common thyroid cancers.Methodsthis study investigat...

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Main Authors: Maria Eduarda de Castro, Gustavo Forlin de Siqueira, Jean Ferrante Mariano, Marina Malta Letro Kizys, Lucieli Ceolin, Fernando Augusto Soares, Rodrigo Natal, Humberto Carneiro, Rodrigo Nalio Ramos, Laura Sterian Ward, Niels Olsen Saraiva Camara, Cleber Pinto Camacho, Flavia de Oliveira Facuri Valente, Susan Chow Lindsey, Diego Dias dos Santos, Cristiane Damas Gil, João Roberto Maciel Martins, Rui Monteiro de Barros Maciel, Lucas Leite Cunha
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
medullary thyroid carcinoma (MTC)
immune microenvironment
PD-L1 expression
tumor-infiltrating lymphocytes (TILs)
mast cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1579205/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1579205/full

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