Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

<h4>Background</h4>Inhibition of parasite growth is a major objective of blood-stage malaria vaccines. The in vitro assay of parasite growth inhibitory activity (GIA) is widely used as a surrogate marker for malaria vaccine efficacy in the down-selection of candidate blood-stage vaccines...

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Main Authors: Christopher J A Duncan, Susanne H Sheehy, Katie J Ewer, Alexander D Douglas, Katharine A Collins, Fenella D Halstead, Sean C Elias, Patrick J Lillie, Kelly Rausch, Joan Aebig, Kazutoyo Miura, Nick J Edwards, Ian D Poulton, Angela Hunt-Cooke, David W Porter, Fiona M Thompson, Ros Rowland, Simon J Draper, Sarah C Gilbert, Michael P Fay, Carole A Long, Daming Zhu, Yimin Wu, Laura B Martin, Charles F Anderson, Alison M Lawrie, Adrian V S Hill, Ruth D Ellis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0022271&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0022271&type=printable

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