Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study.

Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: A prospective human splenectomy study.

<h4>Background</h4>A very large biomass of intact asexual-stage malaria parasites accumulates in the spleen of asymptomatic human individuals infected with Plasmodium vivax. The mechanisms underlying this intense tropism are not clear. We hypothesised that immature reticulocytes, in whic...

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Main Authors: Steven Kho, Labibah Qotrunnada, Leo Leonardo, Benediktus Andries, Putu A I Wardani, Aurelie Fricot, Benoit Henry, David Hardy, Nur I Margyaningsih, Dwi Apriyanti, Agatha M Puspitasari, Pak Prayoga, Leily Trianty, Enny Kenangalem, Fabrice Chretien, Valentine Brousse, Innocent Safeukui, Hernando A Del Portillo, Carmen Fernandez-Becerra, Elamaran Meibalan, Matthias Marti, Ric N Price, Tonia Woodberry, Papa A Ndour, Bruce M Russell, Tsin W Yeo, Gabriela Minigo, Rintis Noviyanti, Jeanne R Poespoprodjo, Nurjati C Siregar, Pierre A Buffet, Nicholas M Anstey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-05-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1003632
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https://doi.org/10.1371/journal.pmed.1003632

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