IP6K2 mutations as a novel mechanism of resistance to oncolytic virus therapy

Abstract Background Oncolytic virus therapy (OVT) represents a promising frontier in cancer treatment. Despite its efficacy in clinical trials, variability in patient response, particularly resistance development, highlights the need for tailored therapeutic strategies. Methods The Inositol Hexakisp...

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Bibliographic Details
Main Authors: Zhijian Huang, Xiangqian Zhao, Zirong Jiang, Xiaoting Qiu, Xinhao Sun, Dawei Wang, Hucheng Zhang, Qi Chen, Ruirong Tan, Yangkun Shen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
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Online Access:https://doi.org/10.1186/s12967-025-06265-0
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