Structural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodies

Abstract The Hepatitis B Virus (HBV) poses a significant health threat, causing millions of deaths each year. Hepatitis B surface antigen (HBsAg), the sole membrane protein on the HBV viral envelope, plays crucial roles in viral attachment to host cells and serves as the target for neutralizing anti...

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Bibliographic Details
Main Authors: Xiao He, Weiyu Tao, Yunlu Kang, Jiaxuan Xu, Xiaoyu Liu, Lei Chen
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00803-2
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