Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration

Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration

Abstract Physiologically, the retinal pigment epithelium (RPE) expresses immunosuppressive signals such as FAS ligand (FASL), which prevents the accumulation of leukocytes in the subretinal space. Age‐related macular degeneration (AMD) is associated with a breakdown of the subretinal immunosuppressi...

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Main Authors: Olivier Levy, Bertrand Calippe, Sophie Lavalette, Shulong J Hu, William Raoul, Elisa Dominguez, Michael Housset, Michel Paques, José‐Alain Sahel, Alexis‐Pierre Bemelmans, Christophe Combadiere, Xavier Guillonneau, Florian Sennlaub
Format: Article
Language:English
Published: Springer Nature 2015-01-01
Series:EMBO Molecular Medicine
Subjects:
age‐related macular degeneration
apolipoprotein E
interleukin 6
mononuclear phagocyte
neuroinflammation
Online Access:https://doi.org/10.15252/emmm.201404524
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https://doi.org/10.15252/emmm.201404524

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