Synthesis and Evaluation of Glucosyl-, Acyl- and Silyl- Resveratrol Derivatives as Retinoprotective Agents: Piceid Octanoate Notably Delays Photoreceptor Degeneration in a Retinitis Pigmentosa Mouse Model

Synthesis and Evaluation of Glucosyl-, Acyl- and Silyl- Resveratrol Derivatives as Retinoprotective Agents: Piceid Octanoate Notably Delays Photoreceptor Degeneration in a Retinitis Pigmentosa Mouse Model

Background: Retinitis pigmentosa (RP), the leading cause of inherited blindness in adults, is marked by the progressive degeneration of rod photoreceptors in the retina. While gene therapy has shown promise in treating RP in patients with specific mutations, no effective therapies currently exist fo...

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Main Authors: Lourdes Valdés-Sánchez, Seyed Mohamadmehdi Moshtaghion, Estefanía Caballano-Infantes, Pablo Peñalver, Rosario Rodríguez-Ruiz, José Luis González-Alfonso, Francisco José Plou, Tom Desmet, Juan C. Morales, Francisco J. Díaz-Corrales
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceuticals
Subjects:
neurodegeneration
retinal degeneration
retinitis pigmentosa
resveratrol
piceid octanoate
retinoprotection
Online Access:https://www.mdpi.com/1424-8247/17/11/1482
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