Ability of protein epitope-containing constructs associated with melanoma to stimulate the cytotoxic activity of peripheral blood mononuclear cells against melanoma cells

Ability of protein epitope-containing constructs associated with melanoma to stimulate the cytotoxic activity of peripheral blood mononuclear cells against melanoma cells

Aim. The aim of the study was to evaluate the ability of pMEL-TCI and pMEL-A0201 DNA-constructs encoding artificial polyepitope melanoma antigens to induce antitumor T cell immune response ex vivo. material and methods. Dendritic cells were obtained from peripheral blood mononuclear cells of HLA-A02...

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Bibliographic Details
Main Authors: E. A. Borobova, D. V. Antonets, E. V. Starostina, L. I. Karpenko, A. A. Zheravin, A. A. Ilyichev, S. I. Bazhan
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2019-02-01
Series:Сибирский онкологический журнал
Subjects:
melanoma
dna-vaccine constructs
t-cell epitopes
artificial immunogens
cytotoxic t-lymphocytes
skin melanoma
immunogens
cytotoxic activity
immune response
Online Access:https://www.siboncoj.ru/jour/article/view/958
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