A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines

A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines

Bromodomain-containing protein 4 (BRD4) is a key protein that drives the development of malignant melanoma and is closely associated with the ferroptosis signaling pathway. Degradation of BRD4 can downregulate the expression of ferroptosis-related genes such as GPX4, thereby promoting tumor-specific...

Full description

Saved in:
Bibliographic Details
Main Authors: Linghong Huang, Xinyuan Sun, Qinhua Zuo, Ting Song, Ning Liu, Zonghua Liu, Wei Xue
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Materials Today Bio
Subjects:
In situ tumor vaccines
Antigen presentation
PROTAC
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S259000642500081X
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S259000642500081X

Similar Items