Novel mRNA-Engineered Fully Human CAR-T Cells Targeting AXL in Solid Tumors

Novel mRNA-Engineered Fully Human CAR-T Cells Targeting AXL in Solid Tumors

<b>Background/Objectives:</b> The AXL receptor tyrosine kinase is a promising therapeutic target in solid tumors, yet conventional viral vector-engineered CAR-T cells face critical limitations, including risks of insertional mutagenesis and immunogenicity from murine-derived single-chain...

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Bibliographic Details
Main Authors: Bo Zou, Mengge Wang, Shimeng Bai, Ning Li, Zhongyi Fan, Yuanzheng Peng, Mingshu Han, Chen Zeng, Hongzhou Lu, Lin Qi, Xingding Zhang, Xiaohua Tan, Qibin Liao
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomedicines
Subjects:
AXL
mRNA
fully human CAR-T
solid tumors
immunotherapy
Online Access:https://www.mdpi.com/2227-9059/13/4/844
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