Nimbolide Targeting SIRT1 Protects Against Acetaminophen‐Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

Nimbolide Targeting SIRT1 Protects Against Acetaminophen‐Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

ABSTRACT Acetaminophen (APAP) is a major cause of acute liver injury (ALI), and N‐acetylcysteine is the only approved detoxification drug. Nimbolide (Nim), which is isolated from the neem tree (Azadirachta indica), possesses protective properties against multiple diseases, including pancreatitis, au...

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Bibliographic Details
Main Authors: Junhui Ba, Yunsen Lin, Jingcong Zhang, Yanhong Wang, Benquan Wu
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Pharmacology Research & Perspectives
Subjects:
APAP
ER stress
nimbolide
SIRT1
Online Access:https://doi.org/10.1002/prp2.70120
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https://doi.org/10.1002/prp2.70120

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