Relationship between blood-cerebrospinal fluid barrier integrity, cardiometabolic, and inflammatory factors in schizophrenia-spectrum disorders

Relationship between blood-cerebrospinal fluid barrier integrity, cardiometabolic, and inflammatory factors in schizophrenia-spectrum disorders

The blood-cerebrospinal fluid barrier (BCB) is impaired in a substantial proportion of individuals with schizophrenia-spectrum disorders (SSD). Even though disruption of the BCB is associated with higher symptom severity, factors linked to BCB disruption in SSDs have been minimally investigated.To a...

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Main Authors: Vladislav Yakimov, Iris Jäger, Lukas Roell, Emanuel Boudriot, Verena Meisinger, Mattia Campana, Lenka Krčmář, Sean Halstead, Nicola Warren, Dan Siskind, Isabel Maurus, Alkomiet Hasan, Peter Falkai, Andrea Schmitt, Florian J. Raabe, Daniel Keeser, Elias Wagner, Joanna Moussiopoulou
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Psychosis
CNS barriers
Cardiovascular health
Immunity
Cerebroventricular system
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354625000821
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