ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development

ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development

Abstract: Alterations inactivating the tumor suppressor gene PTEN drive the development of solid and hematologic cancers, such as T-cell acute lymphoblastic leukemia (T-ALL), in which phosphatase and tensin homolog (PTEN) loss defines poor-prognosis patients. We investigated the metabolic rewiring i...

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Main Authors: Guillaume P. Andrieu, Guillaume Hypolite, Mehdi Latiri, Estelle Balducci, Caroline Costa, Els Verhoeyen, Marianne Courgeon, Omran Allatif, Ivan Nemazanyy, Ganna Panasyuk, Kathryn Wellen, Daniel Herranz, Laurent Genestier, Elizabeth Macintyre, Vahid Asnafi, Melania Tesio
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S247395292400658X
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