Precision prediction of intervertebral disc degeneration in ankylosing spondylitis using a nomogram model reveals the pivotal role of Th2-type immune dysregulation

Precision prediction of intervertebral disc degeneration in ankylosing spondylitis using a nomogram model reveals the pivotal role of Th2-type immune dysregulation

BackgroundAnkylosing spondylitis (AS) is an immune-mediated chronic inflammatory disease. When AS is complicated by intervertebral disc degeneration (IVDD), disease complexity increases substantially, often resulting in poor long-term outcomes. Although previous studies have explored the mechanisms...

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Bibliographic Details
Main Authors: Xiao-nan Wang, Xiao-tian Ma, Jie Li, Run-tian Zhou, Yuan-zhang Jin, Xiao-feng Zhao, Dou-dou Jing, Bin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
precision medicine
ankylosing spondylitis
intervertebral disc degeneration
nomogram
Th2 cells
IL-4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1556738/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1556738/full

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