The supporting role of Schwann cells in perineural invasion of pancreatic ductal adenocarcinoma

The supporting role of Schwann cells in perineural invasion of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with tumor cells readily disseminating to other organs through the bloodstream, lymphatic system, and nervous system, thereby impacting patients’ survival rates. PDAC is often associated with perineural invasion (PNI), which not...

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Bibliographic Details
Main Authors: Yun He, Zheng Chen, Liu Yang, Shuanying Qiao, Zonghua Su, Feng Ding, Fadian Ding, Fuli Xin, Siyu Xiang, Aiping Lyu, Fangfei Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
pancreatic ductal adenocarcinoma
perineural invasion
Schwann cells
tumor microenvironment
peripheral nervous system
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1540027/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1540027/full

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