Single-cell analysis reveals that GFAP+ dedifferentiated Schwann cells promote tumor progress in PNI-positive distal cholangiocarcinoma via lactate/HMGB1 axis

Single-cell analysis reveals that GFAP+ dedifferentiated Schwann cells promote tumor progress in PNI-positive distal cholangiocarcinoma via lactate/HMGB1 axis

Abstract Distal cholangiocarcinoma (dCCA) is a highly lethal malignancy that accounts for approximately 40% of patients with primary cholangiocarcinoma. Remarkable cellular heterogeneity and perineural invasion (PNI) are two typical features of dCCA. Deciphering the complex interplay between neoplas...

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Main Authors: Ziyang Zu, Chong Zhang, Jianxiang Shi, Kunlun Chen, Hongwei Tang, Kaizhao Hu, Enchi Liu, Chengyang Ji, Ruo Feng, Xiaojing Shi, Wenlong Zhai
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07543-x
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https://doi.org/10.1038/s41419-025-07543-x

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