Mutations in hnRNP A1 drive neurodegeneration and alternative RNA splicing of neuronal gene targets

Mutations in hnRNP A1 drive neurodegeneration and alternative RNA splicing of neuronal gene targets

RNA binding protein dysfunction is a pathogenic feature of multiple neurological diseases, including multiple sclerosis (MS). Neurodegeneration (the loss of, or damage to neurons and axons) is the primary driver of disease progression in MS. Herein, we utilized a novel, neuron-specific model of neur...

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Bibliographic Details
Main Authors: Ansalna Ansari, Patricia A. Thibault, Hannah E. Salapa, Joseph-Patrick W.E. Clarke, Michael C. Levin
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
Transcriptomics
In vitro MS model
Differential splicing
Neuronal degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000300
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