The SRG rat as a novel host for an orthotopic patient-derived xenograft model of breast cancer brain metastasis

The SRG rat as a novel host for an orthotopic patient-derived xenograft model of breast cancer brain metastasis

Abstract Patient-derived xenograft (PDX) models are essential for understanding the pathophysiology and developing treatment strategies for breast cancer brain metastasis (BCBM). While immunodeficient mouse models allow for human BCBM growth, their small size limits host survival, neurological imagi...

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Main Authors: Niveen Fulcher, Hien Nguyen, Andrew Deweyert, Mila Uzelac, Maryam Mozaffari, Qi Zhang, John A. Ronald, John J. Kelly, Ying Xia, Timothy J. Scholl, Fallon K. Noto, Diane Begemann, Michael J. Schlosser, Susanne Schmid, Matthew O. Hebb
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-06090-x
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https://doi.org/10.1038/s41598-025-06090-x

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