Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox

Abstract Pre- and post-transcriptional mechanisms, including alternative promoters, termination signals, and splicing, play essential roles in diversifying protein output by generating distinct RNA and protein isoforms. Two major challenges in characterizing the cellular function of alternative isof...

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Main Authors: Megan D. Schertzer, Andrew Stirn, Keren Isaev, Laura Pereira, Stella H. Park, Anjali Das, Aline Réal, Erin D. Jeffery, Claire Harbison, Hans-Hermann Wessels, Gloria M. Sheynkman, Neville E. Sanjana, David A. Knowles
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62066-5
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https://doi.org/10.1038/s41467-025-62066-5

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