The nature of the post-translational modifications of the autoantigen LL37 influences the autoreactive T-helper cell phenotype in psoriasis

The nature of the post-translational modifications of the autoantigen LL37 influences the autoreactive T-helper cell phenotype in psoriasis

Psoriasis is a chronic skin disease evolving to psoriatic arthritis (PsA) in 30% of cases. LL37 is a psoriasis T-cell autoantigen and, in complex with self-DNA/RNA, a trigger of type I interferon (IFN-I) and pro-inflammatory factors in dendritic cells. LL37 can undergo irreversible post-translationa...

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Bibliographic Details
Main Authors: Roberto Lande, Anna Mennella, Raffaella Palazzo, Rebecca Favaro, Paola Facheris, Flavia Mancini, Giuseppe Ocone, Elisabetta Botti, Mario Falchi, Immacolata Pietraforte, Curdin Conrad, Luca Bianchi, Antonio Costanzo, Loredana Frasca
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
psoriasis
autoreactive responses
carbamylation
citrullination
autoantigens
LL37
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546422/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546422/full

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