Myeloid‐Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations

Myeloid‐Derived Suppressor Cells in Cancer: Mechanistic Insights and Targeted Therapeutic Innovations

ABSTRACT Myeloid‐derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that expand aberrantly in cancer and exhibit potent immunosuppressive properties. They contribute to tumor progression through both immunological and nonimmunological mechanisms. Immunologicall...

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Main Authors: Tianying Hu, Jianxue Zhai, Zhanda Yang, Jiajia Peng, Chuxuan Wang, Xinyao Liu, Yawen Li, Jiaqi Yao, Fengxi Chen, Haixia Li, Taixue An, Zongcai Liu, Haifang Wang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:MedComm
Subjects:
myeloid‐derived suppressor cells (MDSCs)
MDSC phenotype
tumor microenvironment (TME)
tumor‐promoting mechanisms
biomarker potential
therapeutic strategy
Online Access:https://doi.org/10.1002/mco2.70231
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https://doi.org/10.1002/mco2.70231

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