Autophagy-related biological targets and network mechanisms of juglone against bladder cancer

Autophagy-related biological targets and network mechanisms of juglone against bladder cancer

Abstract Objective This study aimed to explore juglone’s mechanism in inducing autophagy and apoptosis in bladder cancer (BLCA) via network pharmacology and experimental validation. Methods Juglone’s effects on BLCA cell proliferation, apoptosis, and autophagy were assessed using CCK-8, flow cytomet...

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Bibliographic Details
Main Authors: Yuanfeng Zhang, Enguang Yang, Xinyu Zhang, Ze Zhang, Guoxin Huang, Baoyuan Tang, Chaohu Chen, Longhui Lai, Zixu Pei, Yonghai Zhang, Zhiping Wang
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Journal of Cancer Research and Clinical Oncology
Subjects:
Network pharmacology
Juglone
Bladder cancer
Autophagy
PI3K/AKT pathway
Online Access:https://doi.org/10.1007/s00432-025-06243-5
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https://doi.org/10.1007/s00432-025-06243-5

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