Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction

Development of a high-throughput TR-FRET assay to identify inhibitors of the FAK-paxillin protein-protein interaction

Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase and scaffolding protein that is primarily regulated by integrin signaling. FAK signaling increases cell motility in both normal and cancer cells, and FAK is often overexpressed and/or dysregulated in many types of cancer. FAK has three di...

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Bibliographic Details
Main Authors: Rukayat Aromokeye, Martha Ackerman-Berrier, Rosa del Carmen Araujo, Maria Lambousis, Savio Cardoza, L. Charlie Chen, Matthew E. Kaplan, Haining Zhu, Christopher Penton, Celina Zerbinatti, Gregory R.J. Thatcher, Timothy Marlowe
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:SLAS Discovery
Subjects:
Cancer drug discovery
Protein-protein interactions
Fibrosis
Small molecules
High-throughput screening
Surface plasmon resonance
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000309
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